The Contact Phase of Blood Coagulation in Diabetes Mellitus and in Patients with Vasculopathy

Summary

The contact phase has been studied in diabetics and patients with macroangiopathy. Factor XII and high molecular weight kininogen (HMWK) are normal. C₁-inhibitor and also α₂-macroglobulin are significantly elevated in diabetics with complications, for α₁-macroglobulin especially in patients with nephropathy, 137.5% ± 36.0 (p <0.001). C₁-inhibitor is also increased in vasculopathy without diabetes 113.2 ± 22.1 (p <0.01).

Prekallikrein (PK) is increased in all patients’ groups (Table 2) as compared to normals. PK is particularly high (134% ± 32) in 5 diabetics without macroangiopathy but with sensomotor neuropathy. This difference is remarkable because of the older age of diabetics and the negative correlation of PK with age in normals.

Key words

Diabetes mellitus - Neuropathy - Prekallikrein - Contact phase

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